{"type":"standard","title":"CP-94253","displaytitle":"CP-94253","namespace":{"id":0,"text":""},"wikibase_item":"Q5013587","titles":{"canonical":"CP-94253","normalized":"CP-94253","display":"CP-94253"},"pageid":20766733,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/9/9c/CP-94253_Structure.svg/330px-CP-94253_Structure.svg.png","width":320,"height":231},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/9/9c/CP-94253_Structure.svg/5663px-CP-94253_Structure.svg.png","width":5935,"height":4293},"lang":"en","dir":"ltr","revision":"1281023608","tid":"b6b52f3d-0371-11f0-af62-c941275e9074","timestamp":"2025-03-17T20:52:18Z","description":"Potent and selective serotonin 5-HT1B receptor agonist","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/CP-94253","revisions":"https://en.wikipedia.org/wiki/CP-94253?action=history","edit":"https://en.wikipedia.org/wiki/CP-94253?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:CP-94253"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/CP-94253","revisions":"https://en.m.wikipedia.org/wiki/Special:History/CP-94253","edit":"https://en.m.wikipedia.org/wiki/CP-94253?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:CP-94253"}},"extract":"CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT1D and 5-HT1A receptors. It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain; reducing food intake and promoting satiety; enhancing the reinforcing effects of cocaine; and possible antidepressant effects. A recent study found that \"Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity\" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.","extract_html":"
CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT1D and 5-HT1A receptors. It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain; reducing food intake and promoting satiety; enhancing the reinforcing effects of cocaine; and possible antidepressant effects. A recent study found that \"Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity\" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.
"}{"slip": { "id": 167, "advice": "No one knows anyone else in the way you do."}}
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{"slip": { "id": 131, "advice": "YOLO"}}
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